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Leon Glass (born 1943) is an American scientist who has studied various aspects of the application of mathematical and physical methods to biology, with special interest in vision, cardiac arrhythmia, and genetic networks.
In 1975, Glass joined the department of physiology at McGill University, where he is professor emeritus and the Isadore Rosenfeld chair in Cardiology. He was awarded a Guggenheim Fellowship in 1994 and is a Fellow of the Royal Society of Canada (1998), the American Physical Society (1999), and the Society for Industrial and Applied Mathematics (2009). Leon Glass is a father of two and lives in Montreal, Canada.
Glass is also a French horn player, and is part of the executive committee of the I Medici di McGill Orchestra, an orchestra consisting mainly of McGill University's medical students and professors.
David Marr first coined the term "Glass patterns" in his 1982 work on visual perception, resulting in an increased interest in the phenomenon. Because of their mathematical simplicity and physiological underpinnings, Glass patterns have subsequently been used in dozens of electrophysiology and visual psychophysics experiments, resulting in additional understanding of the physiology of visual perception.
Glass may be best known for his work with colleagues at McGill University, suggesting that certain physiological disorders may be considered dynamical diseases. These are characterized by sudden changes in the qualitative dynamics of a physiological control mechanism, which leads to disease. These features are illustrated in the Mackey-Glass equations. According to James Gleick, who recounted conversations with Glass in his book , foundational work in Chaos theory by the McGill group was performed using animal models. He quotes Glass saying: "Many different rhythms can be established between a stimulus and a little piece of chicken heart". Since the initial description of dynamical diseases, a large number of researchers have analyzed mathematical models of physiological systems. Examples of dynamical diseases have been described in medical fields as diverse as hematology, cardiology, neurology, and psychiatry. (2025). 9783540427629, Springer. ISBN 9783540427629 Dynamical disease modeling has been used to understand cardiac arrhythmia, and specific model detection algorithms are now being programmed into pacemakers so that pathological patterns can be detected and corrected.
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